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Table 3 Comparison of top 7 performing alignment strategies of SPIC with the best strategies of existing methods for motif retrieval on Dataset-1.

From: SPIC: A novel similarity metric for comparing transcription factor binding site motifs based on information contents

 

Accuracy

Strategy

ZF PFMs(25)

Non-ZF PFMs(71)

Total(96)

SPIC/SW(gap open = 1.00)

0.620

0.921

0.841

SPIC/SW(gap open = 0.75)

0.613

0.918

0.837

SPIC/SW(gap open = 0.50)

0.614

0.916

0.837

SPIC/SW(gap open = 1.50)

0.605

0.916

0.835

SPIC/SW(gap open = 0.25)

0.606

0.915

0.835

SPIC/SW(ungapped)

0.610

0.916

0.836

SPIC/NW(gap open = 1.0)

0.585

0.793

0.731

KFV(4-mer, cosine angle)

0.600

0.915

0.833

PCC/SWU

0.600

0.887

0.813

SSD/SW

0.560

0.859

0.781

  1. The last three columns are the results for the zinc-finger (ZF), non-ZF, and total families, respectively. The performances of SSD/SW and PCC/SWU are quoted from the STAMP [11]. The data of KFV are quoted from [25]. Gap extension is equal to half the gap open.