The second module identified by iMCMC and the corresponding known pathway in the GBM data. (A) Red and blue colors in the vertex represent the proportion of gene's coverage and the influence of its mutation status on other genes. Thick gray line shows that gene CDKN2B and the metagene CDK4/TSPAN31 are approximately exclusive (with exclusivity more than 0.90), whereas the dashed green curve represents existence of relative correlation between the expressions of the corresponding pair of genes. It is similar for the following figures. (B) CDK4 is suppressed by CDKN2B in the RB signaling pathway, where the interaction is as reported in .