Identification of novel microRNA regulatory pathways associated with heterogeneous prostate cancer

BMC Systems Biology

Table 1 Top 15 enriched GeneGO pathways.

Category	Term	PubMed citation count*
Development	Ligand-independent activation of ESR1 and ESR2^§
Development	Role of HDAC and calcium / calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
Development	Neurotrophin family signalling
Development	Membrane-bound ESR1: interaction with growth factors signalling§
Translation	Regulation of EIF2 activity
Translation	Insulin regulation of translation	1
Development	IGF-1 receptor signalling	3
Transcription	Receptor-mediated HIF regulation
Immune response	IL-15 signalling
Development	PIP3 signalling in cardiac myocytes
Signal transduction	Activin A signalling regulation
Apoptosis and survival	BAD phosphorylation §	10
Neurophysiological process	NMDA-dependent postsynaptic long-term potentiation in CA1 hippocampal neurons
G-protein signalling	Proinsulin C-peptide signalling	1
Development	Thrombopoietin-regulated cell processes

*The citation count was calculated by searching the pathway names in title and abstract fields of PubMed.
^§Pathways with this mark are also in the top15 pathways of our previous study [20].
The following two pathways are novel pathways identified by both the present and the previous studies. 1) Ligand-independent activation of ESR1 and ESR2; 2) Membrane-bound ESR1: interaction with growth factors signalling.

ISSN: 1752-0509