Table 3 GenoMesh analysis of 31 E. coli pathways containing at least 10 genes.

1

superpathway of chorismate

50(61)

0.077

0.134

-10.98

0

2

superpathway of histidine, purine, and pyrimidine biosynthesis

42(58)

0.080

0.117

-10.67

2.91E-275

3

superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass

35(45)

0.074

0.140

-8.39

3.19E-146

4

aspartate superpathway

26(29)

0.080

0.133

-8.06

2.03E-103

5

respiration (anaerobic)

24(30)

0.086

0.170

-8.57

1.87E-108

6

respiration (anaerobic)-- electron donors reaction list

21(31)

0.209

0.260

-25.72

0

7

mixed acid fermentation

21(28)

0.102

0.171

-10.32

5.00E-138

8

superpathway of glyoxylate bypass and TCA

21(24)

0.123

0.190

-11.86

9.88E-182

9

superpathway of lysine, threonine, methionine, and S-adenosyl-L-methionine biosynthesis

21(23)

0.103

0.140

-10.45

1.71E-141

10

tRNA charging pathway

21(23)

0.073

0.107

-6.21

2.18E-51

11

superpathway of threonine metabolism

20(26)

0.133

0.208

-14.37

8.72E-253

12

superpathway of arginine and polyamine biosynthesis

19(22)

0.124

0.135

-11.32

1.46E-152

13

superpathway of phenylalanine, tyrosine, and tryptophan biosynthesis

18(25)

0.148

0.162

-15.52

1.15E-269

14

superpathway of leucine, valine, and isoleucine biosynthesis

17(30)

0.215

0.247

-23.38

0

15

aerobic respiration -- electron donors reaction list

17(21)

0.270

0.286

-30.45

0

16

TCA cycle

17(20)

0.143

0.209

-14.37

2.47E-221

17

respiration (anaerobic)-- electron acceptors reaction list

16(25)

0.194

0.212

-20.18

0

18

superpathway of lipopolysaccharide biosynthesis

15(26)

0.093

0.127

-7.47

1.20E-54

19

superpathway of glycolysis and Entner-Doudoroff

15(22)

0.114

0.126

-9.92

8.82E-95

20

superpathway of fatty acid biosynthesis

12(24)

0.223

0.221

-19.90

0

21

glycolysis I

12(18)

0.113

0.135

-8.61

1.11E-59

22

formylTHF biosynthesis I

12(15)

0.060

0.079

-3.04

4.90E-09

23

methionine and methyl-donor-molecule biosynthesis

11(13)

0.115

0.145

-8.36

1.92E-52

24

superpathway of sulfate assimilation and cysteine biosynthesis

11(12)

0.176

0.225

-14.26

2.72E-148

25

tetrahydrofolate biosynthesis I

11(12)

0.081

0.153

-4.95

1.13E-19

26

de novo biosynthesis of pyrimidine ribonucleotides

11(12)

0.119

0.142

-8.67

3.51E-56

27

peptidoglycan biosynthesis I

11(11)

0.294

0.225

-25.91

0

28

arginine biosynthesis I

11(11)

0.181

0.156

-14.93

3.35E-162

29

de novo biosynthesis of pyrimidine deoxyribonucleotides

10(18)

0.150

0.220

-11.06

4.00E-83

30

chorismate biosynthesis

10(11)

0.210

0.202

-16.58

7.45E-184

31

colanic acid building blocks biosynthesis

10(11)

0.114

0.135

-7.78

3.94E-42