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Figure 5 | BMC Systems Biology

Figure 5

From: Stochastic modelling of biochemical systems of multi-step reactions using a simplified two-variable model

Figure 5

Simulated mRNA degradation dynamics using the estimated model parameters. (A) Deterministic simulations for mRNA numbers from the ACT1 construct (green dash-line: the one-step model (k = 0.0276), red solid-line: the two-variable model with the optimal initial length (k = 0.112, L = 371), black dot-line: the two-variable model with the averaged initial length L= n X 2 , blue dots: experimental data); (B) Deterministic simulations for mRNA numbers from the RPL30 construct (green dash-line: the one-step model (k = 0.0343), red solid-line: the two-variable model with the optimal initial length (k = 0.167, L = 473), black dot-line: the two-variable model with the averaged initial length L= n X 2 (k = 0.161), blue dots: experimental data); (C) Stochastic simulations of the two-variable model for the ACT1 construct (red dot-line: initial X0 = 5, k = 0.115, L = 19, black dash-dot-line:initial X0 = 10, k = 0.111, L = 37, blue dots: experimental data); (D) Stochastic simulations of the two-variable model for the RPL30 construct (red dot-line: initial X0 = 5, k = 0.171, L = 24, black dash-dot-line:initial X0 = 10, k = 0.166, L = 47, blue dots: experimental data).

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