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Table 3 Transition-wise differential co-expression protein interaction subnetworks

From: Dynamic protein interaction modules in human hepatocellular carcinoma progression

Transition # nodes # edges HCC-related genesa Hub genesb
    HCB CGC HCR  
N-C 307 310 28*** 29*** 154* ARRB1, APC, CDKN2A, CSNK2A1, CSNK2A2, EP300, ESR1, GRB2, HCK, MCC, PIK3R1, PPP1CC, SRRM2, SUMO2, TSC22D1, YWHAG, YWHAZ
C-D 102 103 13*** 10* 44 APC, GFI1B, NEDD4, UBE2D3
D-E 104 103 10* 13*** 58* IKBKE, PIK3R1, YWHAZ
E-A 103 102 9* 11* 60* EGFR, FYN, IKBKG, PRMT1,YWHAG
  1. aSee Materials and methods for explanation of the three HCC-related gene sets. Significance levels of HCC-related gene enrichment are labeled by *(p < 0.01) and ***(p < 0.0001).
  2. bHubs are genes with six or more connected neighbors. Hepatitis C virus -binding genes (italicized) and cancer-mutated genes (bold) are marked.