Plot of changes in miRNA expression versus node degree. Each dysregulated miRNA was plotted with the value of the X-axis being the log transformed fold change observed when comparing the M12 cells to the P69 cells. The y-axis represents the sum node degree of all experimentally verified targets of that miRNA. A horizontal line was drawn at 200, which is the mean node degree of all dysregulated miRNA targets. miRNAs with proven roles in cancer progression are identified with a circle whereas miRNAs identified with a square have an unproven role in tumor progression.