Skip to main content


Table 2 Table 2

From: A networks method for ranking microRNA dysregulation in cancer

Pathway Name Description Relevant miRNA Targeted Proteins
Apoptosis Process of programmed cell death APAF1, BAK1, BCL2, BNIP3L, CASP6, CASP7, CDKN2A, FADD, FAS, IGF1R, JUN, MCL1, MYC, PIK3R1
E2F regulation of DNA replication E2F family of transcription factors affects cell cycle progression, apoptosis and DNA synthesis. CCNE1, CDC25A, DHFR, E2F1, E2F2, E2F3, PRIM1, RB1, TYMS
TRKA signaling Activation leads to cell survival and replication ADCY6, AKT2, CDKN1A, CDKN1B, CRK, FOXO1, IRS1, KRAS, MAPK12, MAPK14, MAPK7, MTOR, NRAS, PIK3R1, PTEN, RHOA
miR-17-92 cluster/ E2F Regulation of E2F and Myc by members of miR-17-92 cluster E2F1, E2F2, E2F3, MYC
IL2 signaling events mediated by STAT5 Cytokine signaling pathway involved in immune response to foreign infection BCL2, CCNA2, CCND3, CDK6, FOXP3, JAK1, MYC, PIK3R1, SP1
ErbB Signaling ErbB family of receptor tyrosine kinases regulates motility, survival, apotosis, proliferation CCND1, CDKN1A, CDKN1B, CRK, EGFR, ERBB2, ERBB3, FOXO1, JUN, KRAS, MTOR, MYC
G1/S Transition Cell cycle checkpoint CCND1, CDK4, CDKN1A, CDKN1B, CDKN2A, E2F1, E2F2
IL-4 Signaling Regulates immune response signaling including B cell proliferation, T and B cell survival, production of immunoglobulins, and chemokine production. BCL2, CCNA2, CCND3, CDK6, FOXP3, JAK1, MYC, PIK3R1, SP1
Cell Cycle Cell division, replication, and maturation. CCNA2, CCND3, CCNE1, CDC14B, CDC25A, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, E2F1, E2F2, E2F3, PLK1, RB1