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Figure 2 | BMC Systems Biology

Figure 2

From: Identification of key regulators in glycogen utilization in E. coli based on the simulations from a hybrid functional Petri net model

Figure 2

A HFPN model of extended center metabolism pathway in E. coli. This model includes three major parts: glycolysis and pentose phosphate pathway part, PTS part and glycogen metabolism pathway part, and they are bordered by light green lines respectively. Cyan border and D marked transitions are degradation or dilution processes of their connected metabolites or enzymes. Black border components are of the three major parts. Red border components are of regulatory mechanisms, in which transition ptsG and ptsHIcrr represent PTS genes expression process; G_cAMP is the process of PEIIAGlc activating cAMP production; Dimer is the process of EI dimerization; k is the parameter controlling the whole PTS reaction speed; Location is of the molecular subcellular localization regulation mechanism; (P)HPr::GlgP represent the process of the binding of (P)HPr::GlgP catalyzing glycogen decomposition. This is the snapshot of main part of our HFPN model, other components can be found in Additional files in URL [36].

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