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Table 2 Behaviors of key regulators (HPr and EIIAGlc) adjusting glucose and glycogen utilization in an E. coli..

From: Identification of key regulators in glycogen utilization in E. coli based on the simulations from a hybrid functional Petri net model

Regulator

Lag phase

Log phase

Stationary phase

 

Early

Late

Early

Late

 

speed of glucose uptake

very slow

slow

very fast

fast

no

FDP amount

low

high

low→ high

high→ low

no

α (glgC&glgA activation)

off

on

off→ on

on→ off

off

EIIA Glc phosphorylation

yes→ no

no

no

yes

yes

(regulated cAMP level)

high→ low

low

low

high

high

β (glgC&glgA activation)

on→ off

off

off

on

on

glycogen

γ (composition)

no

slow

slow

fast→ slow

no

 

(decomposition)

slow→ fast

no

no

no

slow

HPr

(phosphorylation)

yes→ no

no

no

yes

yes

 

(localization)

pole

cytosol

cytosol

cytosol

pole

  1. In this table, the five proliferation phases (e.g. Late lag phase) are corresponding with their processes of experiment and simulation data in Figure 4.