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Figure 4 | BMC Systems Biology

Figure 4

From: Inferring functional transcription factor-gene binding pairs by integrating transcription factor binding data with transcription factor knockout data

Figure 4

The percentage distribution of functional binding targets of TFs extracted from the original ChIP-chip dataset. The potential binding target genes were defined by a p-value threshold of 0.01. As the bar chart shows, there is a 'jump' from 23% to 65% of extracted functional binding target genes. Hence, a cut-off that at least 25% of the original binding target genes should be functional was adopted. This gives 72 analysable TFs with their functional binding target genes (ratio of functional binding targets for these 72 analysable TFs: mean = 79.68%, standard deviation = 7.3%). Only parts of the TF names were marked in the plot due to space limitations.

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