Table 3 Selected SNPs of longitudinal hypertension from univariate and multivariate analyses.
From: Multivariate generalized multifactor dimensionality reduction to detect gene-gene interactions
CHR | SNP | Gene symbol | HP1 | HP2 | HP3 | Multivariate | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Â | Â | Â | Beta | P-value | Beta | P-value | Beta | P-value | Beta1 | Beta2 | Beta3 | P-value |
1 | rs4908736 | Â | 0.111 | 6.02E-03 | 0.178 | 8.83E-06 | 0.079 | 5.17E-02 | 0.110 | 0.178 | 0.079 | 1.21E-04 |
4 | rs17675997 | Â | 0.176 | 6.16E-06 | 0.051 | 2.11E-01 | 0.049 | 2.27E-01 | 0.175 | 0.051 | 0.048 | 1.27E-04 |
4 | rs2411259 | LOC152578 | 0.176 | 5.33E-06 | 0.051 | 2.06E-01 | 0.061 | 1.28E-01 | 0.174 | 0.051 | 0.061 | 1.13E-04 |
5 | rs12054837 | ARSB | -0.029 | 4.83E-01 | -0.042 | 3.18E-01 | 0.162 | 2.12E-05 | -0.031 | -0.043 | 0.168 | 2.95E-06 |
5 | rs294082 | Â | 0.067 | 1.02E-01 | 0.087 | 3.28E-02 | 0.181 | 5.80E-06 | 0.068 | 0.087 | 0.181 | 1.71E-04 |
5 | rs17677051 | Â | -0.086 | 3.79E-02 | -0.188 | 7.84E-06 | -0.089 | 3.16E-02 | -0.081 | -0.188 | -0.093 | 8.09E-05 |
5 | rs4867707 | Â | -0.088 | 3.22E-02 | -0.189 | 7.00E-06 | -0.091 | 2.77E-02 | -0.083 | -0.188 | -0.095 | 6.80E-05 |
6 | rs4084097 | Â | 0.163 | 9.61E-06 | -0.004 | 9.27E-01 | 0.092 | 1.68E-02 | 0.158 | -0.005 | 0.095 | 8.05E-06 |
6 | rs7751214 | EPHA7 | -0.191 | 9.16E-06 | -0.009 | 8.26E-01 | -0.099 | 1.85E-02 | -0.190 | -0.008 | -0.100 | 1.39E-05 |
8 | rs4495407 | Â | 0.038 | 3.60E-01 | 0.012 | 7.74E-01 | 0.185 | 8.40E-06 | 0.036 | 0.012 | 0.189 | 5.59E-05 |
8 | rs10956596 | Â | -0.044 | 2.82E-01 | -0.047 | 2.58E-01 | -0.185 | 8.82E-06 | -0.043 | -0.047 | -0.188 | 1.23E-04 |
8 | rs6470947 | Â | 0.053 | 1.94E-01 | 0.023 | 5.69E-01 | 0.187 | 6.69E-06 | 0.053 | 0.023 | 0.190 | 6.05E-05 |
8 | rs4615555 | Â | 0.051 | 2.17E-01 | 0.030 | 4.69E-01 | 0.191 | 3.81E-06 | 0.049 | 0.029 | 0.194 | 3.34E-05 |
8 | rs4279577 | Â | 0.052 | 2.06E-01 | 0.031 | 4.56E-01 | 0.192 | 3.44E-06 | 0.051 | 0.030 | 0.196 | 3.26E-05 |
8 | rs7465333 | Â | 0.050 | 2.31E-01 | 0.031 | 4.57E-01 | 0.189 | 6.33E-06 | 0.048 | 0.031 | 0.193 | 5.75E-05 |
11 | rs550214 | Â | 0.081 | 4.38E-02 | 0.175 | 6.09E-06 | 0.102 | 1.01E-02 | 0.077 | 0.174 | 0.106 | 8.32E-05 |
15 | rs11636344 | FBN1 | 0.075 | 5.81E-02 | 0.167 | 6.51E-06 | 0.035 | 3.88E-01 | 0.073 | 0.166 | 0.037 | 1.06E-04 |
16 | rs17722281 | WWOX | -0.142 | 7.68E-04 | -0.160 | 1.52E-04 | 0.034 | 4.16E-01 | -0.140 | -0.161 | 0.034 | 7.66E-06 |