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Table 1 Examples of highly weighted pharmacogenomic features inferred by the L1LOG method

From: Inferring protein domains associated with drug side effects based on drug-target interaction network

Rank

Weight

Side effect

Protein domain ID

Protein domain definition

1

330.0000

anaphylaxis

PF13558

SbcCD_C (Putative exonuclease SbcCD, C subunit)

2

330.0000

tardive dyskinesia

PF10320

7TM_GPCR_Srsx (Serpentine type 7TM GPCR chemoreceptor Srsx)

3

330.0000

labyrinthitis

PF10316

7TM_GPCR_Srbc (Serpentine type 7TM GPCR chemoreceptor Srbc)

4

330.0000

shortness of breath

PF02898

NO_synthase (Nitric oxide synthase, oxygenase domain)

5

330.0000

priapism

PF10324

7TM_GPC_Srw (Serpentine type 7TM GPCR chemoreceptor Srw)

6

330.0000

nasal congestion

PF10324

7TM_GPCR_Srw (Serpentine type 7TM GPCR chemoreceptor Srw)

7

330.0000

nasal congestion

PF10316

7TM_GPCR_Srbc (Serpentine type 7TM GPCR chemoreceptor Srbc)

8

330.0000

weakness

PF10324

7TM_GPCR_Srw (Serpentine type 7TM GPCR chemoreceptor Srw)

9

327.1335

burning sensation

PF10316

7TM_GPCR_Srbc (Serpentine type 7TM GPCR chemoreceptor Srbc)

10

326.7361

glycosuria

PF00191

Annexin (Annexin)

11

325.3147

shortness of breath

PF10324

7TM_GPCR_Srw (Serpentine type 7TM GPCR chemoreceptor Srw)

12

324.4456

shortness of breath

PF02931

Neur_chan_LBD (Neurotransmitter-gated ion-channel ligand binding domain)

13

320.0000

anaphylaxis

PF00060

Lig_chan (Ligand-gated ion channel)

14

292.0382

hypoventilation

PF02898

NO_synthase (Nitric oxide synthase, oxygenase domain)

15

281.0425

hypoventilation

PF02931

Neur_chan_LBD (Neurotransmitter-gated ion-channel ligand binding domain)