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Table 1 Examples of highly weighted pharmacogenomic features inferred by the L1LOG method

From: Inferring protein domains associated with drug side effects based on drug-target interaction network

Rank Weight Side effect Protein domain ID Protein domain definition
1 330.0000 anaphylaxis PF13558 SbcCD_C (Putative exonuclease SbcCD, C subunit)
2 330.0000 tardive dyskinesia PF10320 7TM_GPCR_Srsx (Serpentine type 7TM GPCR chemoreceptor Srsx)
3 330.0000 labyrinthitis PF10316 7TM_GPCR_Srbc (Serpentine type 7TM GPCR chemoreceptor Srbc)
4 330.0000 shortness of breath PF02898 NO_synthase (Nitric oxide synthase, oxygenase domain)
5 330.0000 priapism PF10324 7TM_GPC_Srw (Serpentine type 7TM GPCR chemoreceptor Srw)
6 330.0000 nasal congestion PF10324 7TM_GPCR_Srw (Serpentine type 7TM GPCR chemoreceptor Srw)
7 330.0000 nasal congestion PF10316 7TM_GPCR_Srbc (Serpentine type 7TM GPCR chemoreceptor Srbc)
8 330.0000 weakness PF10324 7TM_GPCR_Srw (Serpentine type 7TM GPCR chemoreceptor Srw)
9 327.1335 burning sensation PF10316 7TM_GPCR_Srbc (Serpentine type 7TM GPCR chemoreceptor Srbc)
10 326.7361 glycosuria PF00191 Annexin (Annexin)
11 325.3147 shortness of breath PF10324 7TM_GPCR_Srw (Serpentine type 7TM GPCR chemoreceptor Srw)
12 324.4456 shortness of breath PF02931 Neur_chan_LBD (Neurotransmitter-gated ion-channel ligand binding domain)
13 320.0000 anaphylaxis PF00060 Lig_chan (Ligand-gated ion channel)
14 292.0382 hypoventilation PF02898 NO_synthase (Nitric oxide synthase, oxygenase domain)
15 281.0425 hypoventilation PF02931 Neur_chan_LBD (Neurotransmitter-gated ion-channel ligand binding domain)