From: Inferring protein domains associated with drug side effects based on drug-target interaction network
Rank | Weight | Side effect | Protein domain ID | Protein domain definition |
---|---|---|---|---|
1 | 330.0000 | anaphylaxis | PF13558 | SbcCD_C (Putative exonuclease SbcCD, C subunit) |
2 | 330.0000 | tardive dyskinesia | PF10320 | 7TM_GPCR_Srsx (Serpentine type 7TM GPCR chemoreceptor Srsx) |
3 | 330.0000 | labyrinthitis | PF10316 | 7TM_GPCR_Srbc (Serpentine type 7TM GPCR chemoreceptor Srbc) |
4 | 330.0000 | shortness of breath | PF02898 | NO_synthase (Nitric oxide synthase, oxygenase domain) |
5 | 330.0000 | priapism | PF10324 | 7TM_GPC_Srw (Serpentine type 7TM GPCR chemoreceptor Srw) |
6 | 330.0000 | nasal congestion | PF10324 | 7TM_GPCR_Srw (Serpentine type 7TM GPCR chemoreceptor Srw) |
7 | 330.0000 | nasal congestion | PF10316 | 7TM_GPCR_Srbc (Serpentine type 7TM GPCR chemoreceptor Srbc) |
8 | 330.0000 | weakness | PF10324 | 7TM_GPCR_Srw (Serpentine type 7TM GPCR chemoreceptor Srw) |
9 | 327.1335 | burning sensation | PF10316 | 7TM_GPCR_Srbc (Serpentine type 7TM GPCR chemoreceptor Srbc) |
10 | 326.7361 | glycosuria | PF00191 | Annexin (Annexin) |
11 | 325.3147 | shortness of breath | PF10324 | 7TM_GPCR_Srw (Serpentine type 7TM GPCR chemoreceptor Srw) |
12 | 324.4456 | shortness of breath | PF02931 | Neur_chan_LBD (Neurotransmitter-gated ion-channel ligand binding domain) |
13 | 320.0000 | anaphylaxis | PF00060 | Lig_chan (Ligand-gated ion channel) |
14 | 292.0382 | hypoventilation | PF02898 | NO_synthase (Nitric oxide synthase, oxygenase domain) |
15 | 281.0425 | hypoventilation | PF02931 | Neur_chan_LBD (Neurotransmitter-gated ion-channel ligand binding domain) |