Table 5 The top 10 most downregulated genes following transfection and expression of Rnf14 variant 3 and variant 1 transcripts in C2C12 cells
From: RNF14 is a regulator of mitochondrial and immune function in muscle
Rnf14 variant 3 versus controls | Gene ontology | Fold change (Log2) |
|---|---|---|
Dcn | The encoded protein is a small cellular/pericellular matrix proteoglycan | −1.96 |
Myl1 | This gene encodes a fast myosin alkali light chain | −1.76 |
Spon2 | Extracellular matrix protein | −1.63 |
Prelp | The protein encoded by this gene is a leucine-rich repeat protein present in connective tissue extracellular matrix | −1.57 |
Dcn | The encoded protein is a small cellular or pericellular matrix proteoglycan | −1.50 |
Mylk | This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme | −1.24 |
Tgm2 | Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds | −1.20 |
Tnnt1 | This protein is the slow skeletal troponin T subunit | −1.18 |
Htra3 | Proteolysis | −1.17 |
Mylpf | Fast skeletal muscle | −1.16 |
Rnf14 variant 1 versus controls | Gene ontology | Â |
Dcn | The encoded protein is a small cellular or pericellular matrix proteoglycan | −0.88 |
Dcn | The encoded protein is a small cellular or pericellular matrix proteoglycan | −0.75 |
Myl1 | This gene encodes a fast myosin alkali light chain | −0.67 |
Prelp | The protein encoded by this gene is a leucine-rich repeat protein present in connective tissue extracellular matrix | −0.67 |
Spon2 | Extracellular matrix, innate immune response | −0.62 |
Col6a2 | Collagens are extracellular matrix proteins and have a triple-helical domain | −0.60 |
Enpp1 | The encoded protein is a type II transmembrane glycoprotein | −0.57 |
1190002H23Rik (Rgc32) | Cell cycle | −0.55 |
Islr | Immunoglobulin superfamily containing leucine-rich repeat | −0.54 |
C1qtnf3 (Cors) | Beta oxidation, peroxisomal metabolism | −0.53 |