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Table 5 The top 10 most downregulated genes following transfection and expression of Rnf14 variant 3 and variant 1 transcripts in C2C12 cells

From: RNF14 is a regulator of mitochondrial and immune function in muscle

Rnf14 variant 3 versus controls Gene ontology Fold change (Log2)
Dcn The encoded protein is a small cellular/pericellular matrix proteoglycan −1.96
Myl1 This gene encodes a fast myosin alkali light chain −1.76
Spon2 Extracellular matrix protein −1.63
Prelp The protein encoded by this gene is a leucine-rich repeat protein present in connective tissue extracellular matrix −1.57
Dcn The encoded protein is a small cellular or pericellular matrix proteoglycan −1.50
Mylk This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme −1.24
Tgm2 Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds −1.20
Tnnt1 This protein is the slow skeletal troponin T subunit −1.18
Htra3 Proteolysis −1.17
Mylpf Fast skeletal muscle −1.16
Rnf14 variant 1 versus controls Gene ontology  
Dcn The encoded protein is a small cellular or pericellular matrix proteoglycan −0.88
Dcn The encoded protein is a small cellular or pericellular matrix proteoglycan −0.75
Myl1 This gene encodes a fast myosin alkali light chain −0.67
Prelp The protein encoded by this gene is a leucine-rich repeat protein present in connective tissue extracellular matrix −0.67
Spon2 Extracellular matrix, innate immune response −0.62
Col6a2 Collagens are extracellular matrix proteins and have a triple-helical domain −0.60
Enpp1 The encoded protein is a type II transmembrane glycoprotein −0.57
1190002H23Rik (Rgc32) Cell cycle −0.55
Islr Immunoglobulin superfamily containing leucine-rich repeat −0.54
C1qtnf3 (Cors) Beta oxidation, peroxisomal metabolism −0.53
  1. Genes may be represented by more than one probe. The controls are a combination of untransfected cells and cells transfected with an empty construct.