Skip to main content

Table 7 Top 10 transcriptional regulators showing the highest absolute, average co-expression to all the genes in the bovine muscle immune module

From: RNF14 is a regulator of mitochondrial and immune function in muscle

Transcriptional regulator (average correlation to immune module) Gene ontology
IRF1 (0.905) IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 also functions as a transcription activator of genes induced by interferons α, β and γ. Further, IRF1 has been shown to play roles in regulating apoptosis
RNF14 (0.901) This protein interacts with androgen receptor (AR) and may function as a co-activator that induces AR target gene expression
TEAD1 (0.872) This gene encodes a ubiquitous transcriptional enhancer factor that is a member of the TEA/ATTS domain family
LRRFIP1 (0.849) Phosphorylated in response to immunologic stimuli
EPAS1 (0.845) Myoblast cell fate commitment
NR1D2 (0.844) Nuclear Hormone Receptor involved in carbohydrate and lipid metabolism
RORC (0.841) Regulates IL2 expression. IL2 is an inflammatory cytokine
PCGF5 (0.840) Little known
PHF12 (0.838) Little known
HOXD8 ( 0.838) The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis