Table 7 Top 10 transcriptional regulators showing the highest absolute, average co-expression to all the genes in the bovine muscle immune module
From: RNF14 is a regulator of mitochondrial and immune function in muscle
Transcriptional regulator (average correlation to immune module) | Gene ontology |
|---|---|
IRF1 (0.905) | IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 also functions as a transcription activator of genes induced by interferons α, β and γ. Further, IRF1 has been shown to play roles in regulating apoptosis |
RNF14 (0.901) | This protein interacts with androgen receptor (AR) and may function as a co-activator that induces AR target gene expression |
TEAD1 (0.872) | This gene encodes a ubiquitous transcriptional enhancer factor that is a member of the TEA/ATTS domain family |
LRRFIP1 (0.849) | Phosphorylated in response to immunologic stimuli |
EPAS1 (0.845) | Myoblast cell fate commitment |
NR1D2 (0.844) | Nuclear Hormone Receptor involved in carbohydrate and lipid metabolism |
RORC (0.841) | Regulates IL2 expression. IL2 is an inflammatory cytokine |
PCGF5 (0.840) | Little known |
PHF12 (0.838) | Little known |
HOXD8 ( 0.838) | The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis |