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Table 1 Most influential genes

From: Influence networks based on coexpression improve drug target discovery for the development of novel cancer therapeutics

  Untreated 14 Days Letrozole 90 Days Letrozole
Rank Entrez ID Gene symbol Entrez ID Gene symbol Entrez ID Gene symbol
1 28978 TMEM14A 79776 ZFHX4 1727 CYB5R3
2 1843 DUSP1 4701 NDUFA7 7083 TK1
3 51022 GLRX2 715 C1R 1292 COL6A2
4 1434 CSE1L 79818 ZNF552 857 CAV1
5 8522 GAS7 4046 LSP1 5437 POLR2H
6 51668 HSPB11 1727 CYB5R3 9833 MELK
7 10456 HAX1 357 SHROOM2 54861 SNRK
8 9902 MRC2 283298 OLFML1 4830 NME1
9 4706 NDUFAB1 23179 RGL1 231 AKR1B1
10 23560 GTPBP4 1809 DPYSL3 10418 SPON1
11 79633 FAT4 857 CAV1 2350 FOLR2
12 10418 SPON1 274 BIN1 10979 FERMT2
13 471 ATIC 79833 GEMIN6 11096 ADAMTS5
14 6403 SELP 11222 MRPL3 4638 MYLK
15 23421 ITGB3BP 23244 PDS5A 9448 MAP4K4
16 23452 ANGPTL2 6241 RRM2 54922 RASIP1
17 54861 SNRK 1289 COL5A1 6934 TCF7L2
18 2034 EPAS1 8434 RECK 4072 EPCAM
19 30008 EFEMP2 429 ASCL1 4701 NDUFA7
20 25999 CLIP3 3426 CFI 404672 GTF2H5
21 4311 MME 332 BIRC5 6241 RRM2
22 4747 NEFL 2 A2M 2192 FBLN1
23 1809 DPYSL3 10730 YME1L1 25959 KANK2
24 28998 MRPL13 11130 ZWINT 55651 NHP2
25 25959 KANK2 1292 COL6A2 5050 PAFAH1B3
  1. Lists of the top 25 of most influential genes in influence networks based on coexpression among genes in ER + breast tumors before, during, and after a course of neoadjuvant treatment with the drug letrozole. Bold font indicates genes that are also classified as hub-bottleneck genes.
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