T cell PPI Network and essential genes enrichment. After removing non-immunome genes and immunome genes without the lethality annotations, we calculated the hypergeometric distribution and Fisher’s exact test for significance. The figure demonstrates the enrichment of essential genes across almost every component of the TPPIN and for the whole network (p-value = 1.37 × 10-10). The node labels are gene identifiers for the genes coding the proteins. The nodes colored red represent essential genes. The essential genes data is based on the human orthologs of the mouse lethality genes from the Mouse Genome Informatics database.