Figure 2

Model-data comparison and heterogeneity source and pathway analysis. (A) Damage (m _D /m) vs. age (n _B ). Data from [33]. (B) Tsl1 expression (e _Tsl1 ) distribution of cells. (C) Age (n _B ) vs. Tsl1 expression (e _Tsl1 ). (D) Heat shock survival of various Tsl1-sorted fractions. Data from [15]. “a.u.” is arbitrary units. (E) Distribution of heat shock tolerance for base case and various diagnostic simulations (e.g. “dam” has equal damage partitioning, s _d  = 0.5). (F) Heterogeneity network. Line weight indicates contribution of node or link to overall heterogeneity in heat shock tolerance (based on variance of normalized H _t , e.g., panel E). For details of experiments used to generate the data the reader is referred to the source publications.