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Figure 4 | BMC Systems Biology

Figure 4

From: An efficient graph theory based method to identify every minimal reaction set in a metabolic network

Figure 4

Recursive MILP approach for identifying all minimal Additional Reaction Groups (ARGs). After finding an optimal solution, other candidate solutions are generated through substitutability analysis and verified. A new constraint is added to the math program corresponding to each optimal solution, which drives the optimizer to a different optimal solution in the next recursion. The different ARGs identified in Phase 2 together with the Essential Reaction Groups (SRGs) form the various minimal reaction sets.

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