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Table 1 PubMed and PMC searches for OI-MET genes and cancer, BC, PC, and MET

From: A bioinformatics approach reveals novel interactions of the OVOL transcription factors in the regulation of epithelial – mesenchymal cell reprogramming and cancer progression

For 739 OI-MET genes, number found in:

PubMed queries for

% PubMed

p-value

PMC queries for

% PMC

p-value

(“cancer”[Text Word] + OR + “neoplasms”[Text Word])

521

70.5%

< 0.01

703

95.1%

< 0.01

(“breast cancer”[Text Word] + OR + “breast neoplasms”[Text Word])

344

46.5%

< 0.01

699

94.6%

< 0.01

(“prostate cancer”[Text Word] + OR + “prostate neoplasms”[ Text Word])

228

30.9%

< 0.01

679

91.9%

< 0.01

(“epithelial- mesenchymal transition”[ MeSH Terms])

91

12.3%

< 0.0001

292

39.5%

< 0.0001

For All 36, 973 HGNC Genes, Number found in:

PubMed queries for

  

PMC queries for

% PMC

 

(“epithelial- mesenchymal transition”[ MeSH Terms])

995

2.7%

 

1669

4.5%

 
  1. “Cancer”, “breast cancer”, and “prostate cancer” text word searches show that a high proportion of OI-MET genes are associated with these concepts in the literature. “Epithelial-mesenchymal transition” MeSH term searches show a significant enrichment of this annotation in the OI-MET set, relative to all genes: 12.3% ÷ 2.7% = 4.6 Fold Enrichment for PubMed; 39.5% ÷ 4.5% = 8.8 Fold Enrichment for PMC; both with p-value < 0.0001.