Skip to main content

Table 10 AP1 (FOS and JUN) with MYC peak occupancy in the OI-MET gene set, based on ChIPBase datasets

From: A bioinformatics approach reveals novel interactions of the OVOL transcription factors in the regulation of epithelial – mesenchymal cell reprogramming and cancer progression

JUN Peak occupancy (# of JUN and MYC peaks overlapping promoters, of 4, 102 promoters)
  MET
  Only JUN Only MYC Both expected Both observed Fold change P -value
Peaks overlapping promoters 796 305 0.43 152 350.51 <0.0001**
Peaks 120679 19030     
  Non- MET
  Only JUN Only MYC Both expected Both observed Fold change P- value
Peaks overlapping promoters 757 910 0.31 670 2145.60 <0.0001**
Peaks 112929 80131     
FOS Peak occupancy (# of FOS and MYC peaks overlapping promoters, of 4, 102 promoters)
  MET
  Only FOS Only MYC Both expected Both observed Fold change P- value
Peaks overlapping promoters 34 305 0.68 17 24.96 <0.0001**
Peaks 3282 19030     
  Non- MET
  Only FOS Only MYC Both expected Both observed Fold change P- value
Peaks overlapping promoters 251 910 0.31 253 804.10 <0.0001**
Peaks 37162 80131     
  1. Peak occupancy is significantly enriched for both JUN and FOS with MYC, for both the MET and Non-MET models, relative to the expected if they were independent. This result is consistent with cooperative regulation of a subset of these promoters by AP1 and MYC. (**Significant at 0.0001 P-value).