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Table 5 Promoters for the OI-MET gene set, proportion with TF motifs tested singly and compared to all promoters

From: A bioinformatics approach reveals novel interactions of the OVOL transcription factors in the regulation of epithelial – mesenchymal cell reprogramming and cancer progression

  AP1 MAFF ATF3 MYC IRF6 NFKB1 OVOL STAT MYB
Motif name V$AP1F V$AP1R V$CREB V$EBOX V$IRFF V$NFKB V$OVOL V$STAT V$MYBL
# sequences with motif 1380 3193 3267 2472 2696 2386 1467 3191 2873
p- value 5.9E-01 3.1E- 02 7.7E-01 3.8E- 08 1.0E + 00 3.9E- 27 1.0E + 00 9.9E-01 1.0E + 00
Observed proportion 33.6% 77.8% 79.6% 60.3% 65.7% 58.2% 35.8% 77.8% 70.0%
Expected proportion 33.8% 76.6% 80.1% 56.1% 70.5% 49.8% 41.1% 79.4% 74.7%
Fold enrichment 0.995 1.016 0.994 1.074 0.932 1.168 0.870 0.980 0.938
  1. When tested singly, only MAFF, MYC, and NFKB motifs are enriched in promoters from the OI-MET gene set.
  2. Values in bold are significant at the p-value < 0.05 level.
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BMC Systems Biology

ISSN: 1752-0509

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