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Table 7 AP1 (FOS and JUN) promoter occupancy in the OI-MET gene set, based on ChIPBase datasets

From: A bioinformatics approach reveals novel interactions of the OVOL transcription factors in the regulation of epithelial – mesenchymal cell reprogramming and cancer progression

  Promoter occupancy (number of promoters overlapping with at least one peak)
JUN     
  Not _cancer MET   
Promoters with one or more peaks 277 503   
Peaks 75474 120679 Fold change P- value
Promoter occupancy rate 0.367% 0.417% 1.14 0.0966
  not _cancer Non-MET   
Promoters with one or more peaks 277 483   
Peaks 75474 112929 Fold change P- value
Promoter occupancy rate 0.367% 0.428% 1.17 0.0463*
  MET Non-MET   
Promoters with one or more peaks 503 483   
Peaks 120679 112929 Fold change P- value
Promoter occupancy rate 0.417% 0.428% 1.05 0.7083
FOS     
  Not _cancer MET   
Promoters with one or more peaks 119 43   
Peaks 20695 3282 Fold change P- value
Promoter occupancy rate 0.575% 1.310% 2.28 <0.0001**
  Not _cancer Non-MET   
Promoters with one or more peaks 119 161   
Peaks 20695 37162 Fold change P- value
Promoter occupancy rate 0.575% 0.433% 0.75 0.0226*
  MET Non-MET   
Promoters with one or more peaks 43 161   
Peaks 3282 37162 Fold change P- value
Promoter occupancy rate 1.310% 0.433% 0.33 <0.0001**
  1. Promoter occupancy is slightly increased for JUN in both the MET and Non-MET models, relative to the non-cancer model, and there is essentially no difference in rates between the two models. Promoter occupancy is significantly increased for FOS in the MET model but is decreased in the Non-MET model, relative to the non-cancer model. The difference is highly significant. (*Significant at 0.05 P-value. **Significant at 0.001 P-value).
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BMC Systems Biology

ISSN: 1752-0509

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