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Table 7 AP1 (FOS and JUN) promoter occupancy in the OI-MET gene set, based on ChIPBase datasets

From: A bioinformatics approach reveals novel interactions of the OVOL transcription factors in the regulation of epithelial – mesenchymal cell reprogramming and cancer progression

 

Promoter occupancy (number of promoters overlapping with at least one peak)

JUN

    
 

Not _cancer

MET

  

Promoters with one or more peaks

277

503

  

Peaks

75474

120679

Fold change

P- value

Promoter occupancy rate

0.367%

0.417%

1.14

0.0966

 

not _cancer

Non-MET

  

Promoters with one or more peaks

277

483

  

Peaks

75474

112929

Fold change

P- value

Promoter occupancy rate

0.367%

0.428%

1.17

0.0463*

 

MET

Non-MET

  

Promoters with one or more peaks

503

483

  

Peaks

120679

112929

Fold change

P- value

Promoter occupancy rate

0.417%

0.428%

1.05

0.7083

FOS

    
 

Not _cancer

MET

  

Promoters with one or more peaks

119

43

  

Peaks

20695

3282

Fold change

P- value

Promoter occupancy rate

0.575%

1.310%

2.28

<0.0001**

 

Not _cancer

Non-MET

  

Promoters with one or more peaks

119

161

  

Peaks

20695

37162

Fold change

P- value

Promoter occupancy rate

0.575%

0.433%

0.75

0.0226*

 

MET

Non-MET

  

Promoters with one or more peaks

43

161

  

Peaks

3282

37162

Fold change

P- value

Promoter occupancy rate

1.310%

0.433%

0.33

<0.0001**

  1. Promoter occupancy is slightly increased for JUN in both the MET and Non-MET models, relative to the non-cancer model, and there is essentially no difference in rates between the two models. Promoter occupancy is significantly increased for FOS in the MET model but is decreased in the Non-MET model, relative to the non-cancer model. The difference is highly significant. (*Significant at 0.05 P-value. **Significant at 0.001 P-value).