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Table 8 AP1 (FOS and JUN) peak occupancy in the OI-MET gene set, based on ChIPBase datasets

From: A bioinformatics approach reveals novel interactions of the OVOL transcription factors in the regulation of epithelial – mesenchymal cell reprogramming and cancer progression

  Peak occupancy (number of peaks overlapping with promoters)
JUN     
  Not _cancer MET   
Peaks overlapping promoters 287 796   
Peaks 75474 120679 Fold change P- value
Peak occupancy rate 0.38% 0.66% 1.73 <0.0001**
  Not _cancer Non- MET   
Peaks overlapping promoters 287 757   
Peaks 75474 112929 Fold change P- value
Peak occupancy rate 0.38% 0.67% 1.76 <0.0001**
  MET Non- MET   
Peaks overlapping promoters 796 757   
Peaks 120679 112929 Fold change P- value
Peak occupancy rate 0.66% 0.67% 1.02 0.7773
FOS     
  Not _cancer MET   
Peaks overlapping promoters 103 34   
Peaks 20695 3282 Fold Change P- value
Peak occupancy rate 0.50% 1.04% 2.08 0.0003**
  Not _cancer Non-MET   
Peaks overlapping promoters 103 251   
Peaks 20695 37162 Fold Change P- value
Peak occupancy rate 0.50% 0.68% 1.36 0.0105*
  MET Non-MET   
Peaks overlapping promoters 34 251   
Peaks 3282 37162 Fold Change P- value
Peak occupancy rate 1.04% 0.68% 0.65 0.0252*
  1. Peak occupancy is significantly increased for both JUN and FOS, in both the MET and Non-MET models, relative to the non-cancer model. The effect is essentially the same for JUN in the MET and Non-MET models, but the effect for FOS is greater in the MET model. These results are consistent with both JUN and FOS transcription factors trans-locating to occupy the OI-MET promoters in both MET and non-MET models. (*Significant at 0.05 P-value. **Significant at 0.001 P-value).