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Table 9 AP1 (FOS and JUN) with MYC promoter occupancy in the OI-MET gene set, based on ChIPBase datasets

From: A bioinformatics approach reveals novel interactions of the OVOL transcription factors in the regulation of epithelial – mesenchymal cell reprogramming and cancer progression

JUN Promoter occupancy (# promoters overlapping both JUN and MYC peaks, from a total of 4, 102 promoters)
  MET
  Only JUN Only MYC Both expected Both observed Fold change P- value
Promoters with one or more peaks 503 436 53.46 228 4.26 <0.0001**
  Non- MET
  Only JUN Only MYC Both expected Both observed Fold change P- value
Promoters with one or more peaks 483 398 46.86 288 6.15 <0.0001**
FOS Promoter occupancy (# promoters overlapping both FOS and MYC peaks, from a total of 4, 102 promoters)
  MET
  Only FOS Only MYC Both expected Both observed Fold change P- value
Promoters with one or more peaks 43 436 4.57 22 4.81 <0.0001**
  Non- MET
  Only FOS Only MYC Both expected Both observed Fold change P- value
Promoters with one or more peaks 161 398 15.62 100 6.40 <0.0001**
  1. Promoter occupancy is significantly enriched for both JUN and FOS with MYC, for both the MET and Non-MET models, relative to the expected if they were independent. This result is consistent with cooperative regulation of a subset of these promoters by AP1 and MYC. (**Significant at 0.0001 P-value).