Figure 2
From: An integrative modeling framework reveals plasticity of TGF-β signaling
A single unified model of the PID database. The 137 pathways from the PID database containing 27876 biomolecules are integrated into a CADBIOM dynamic model containing 9177 places. Places without input are colored in orange. The insert illustrates an example of regulation by Smad3/Smad 4 and shows the transition of the p21CIP1 gene to p21CIP1 protein, which represents activation of the p21 gene. The condition for the transition contains an extensive logical formula that is not detailed here.