Figure 4

Analysis of the 15934 signaling trajectories containing TGF-β. (A) Schematic representation of the Smad and non-Smad TGF-β cell signaling pathways. (B) Trajectories are clustered according to their content in biomolecules using Euclidian distance metrics. Trajectories that contain Smad protein are colored in red, those that do not in blue and those containing both Smad and non-Smad proteins are in yellow. (C) Functional annotations of TGF-β dependent gene targets using the Database for Annotation, Visualization and Integrated Discovery (DAVID) tool. GOs are colored in grey, blue and red as indicated in the text. ES: extracellular stimuli.