From: Comparisons of Shewanella strains based on genome annotations, modeling, and experiments
Types | Definition | Examples from this study |
---|---|---|
Biomass | Two models being compared have different biomass reactions which cause differences in gene essentiality | Deletion of genes associated with reactions that produce putrescine or spermidine is lethal in all models except the Core because these compounds are not in the Core biomass reaction |
Metabolic | One organism possesses an alternative pathway for an essential reaction | Deletion of genes associated with prephenate dehydrogenase is lethal only in the Core because it does not have an alternative pathway of producing L-tyrosine that the other models have |
Genetic | Difference in the GPR associations between models for essential reactions | Deletion of AsnB (SO2767) is lethal in all models except for i MR1_799 because MR-1 has another isozyme for asparagine synthase, WbpQ (SO3175) |