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Figure 1 | BMC Systems Biology

Figure 1

From: Transcriptional override: a regulatory network model of indirect responses to modulations in microRNA expression

Figure 1

The transcriptional override model (TOM). The network motif (A) typifies how the expected downregulation of target genes by elevated levels of regulating miRNAs may be masked or overridden by target gene derepression mediated by miRNA-induced downregulation of repressor genes. (B) MiRNA-mediated derepression of repressor gene ZNF24 (yellow triangle) overrides the expected downregulatory effects of miRNAs (blue diamonds) on VEGFA expression (blue circle).

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BMC Systems Biology

ISSN: 1752-0509

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