Figure 2

Highly interconnected network of 31 microRNAs, repressors and their mutual targets. Relationships among 31 miRNAs upregulated in cancer (blue diamonds), ten downregulated repressors that are targets of one or more of the upregulated miRNAs (brown triangles) and 843 genes that are the gene targets (blue and yellow circles) of both the upregulated miRNAs and the downregulated repressor genes. Yellow lines depict the regulatory connection between miRNAs and their target genes; blue lines depict the regulatory connection between repressors and target genes. From the perspective of the upregulated miRNAs, all target genes should be downregulated (all yellow circles); from the perspective of the downregulated repressors, all target genes should be derepressed/upregulated (all blue circles). According to TOM, the response of any particular target gene will be determined by the relative strengths of these opposing regulatory controls.