Figure 5

Upregulated repressor targets and downregulated miRNA targets show significant enrichment consistent with TOM. Venn diagrams display the enrichment of A) downregulated targets of miRNAs. The results are consistent with TOM (hypergeometric distribution, p < 1E-12: population = 5910, downregulated genes = 3678, number of predicted miRNA targets = 4829, downregulated miRNA regulated targets = 3206; B) upregulated targets of repressors that are also predicted targets of 1 or more of the 31 upregulated miRNAs. The results are consistent with TOM (hypergeometric distribution, p <1E-12: population = 4829, total upregulated genes = 1623, number of repressor targets = 1205, upregulated repressor targets = 865).