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Table 2 Percentage of miRNA target genes displaying changes in expression between OSE and CEPI

From: Transcriptional override: a regulatory network model of indirect responses to modulations in microRNA expression

Algorithm

Inversely correlated

Positively correlated

No change detected

Total

miRanda-mirSVR

24% (3110)

13% (1719)

62% (8015)

12844

TargetScan

31% (1519)

16% (779)

54% (2681)

4979

SVMicrO

23% (2027)

13% (1164)

64% (5787)

8978

  1. Predicted gene targets of miRNAs were computed independently using three commonly used prediction algorithms: miRanda-mirSVR [7], TargetScan [8] and SVMicrO [9]. For each prediction algorithm, the frequency of target genes displaying changes in gene expression IC, PC or NC with changes in expression of their regulating miRNAs are shown. The number of predicted target genes falling into each class is presented in parentheses.
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BMC Systems Biology

ISSN: 1752-0509

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