Understanding system dynamics of an adaptive enzyme network from globally profiled kinetic parameters

BMC Systems Biology

Table 1 Results of parameter enrichment test for the NFBLB model

Parameter	1^stclass			2^ndclass			3^rdclass			4^thclass			5^thclass
	[10^-3, 10^-2]^a			[10^-2, 10^-1]			[10^-1, 10⁰]			[10⁰, 10¹]			[10¹,10²]
	x ^b	y ^c	p ^d	x	y	p ^d	x	y	p ^d	x	y	p ^d	x	y	p ^d
k _AB							32	49,999	8.5E-01	42	50,001	1.0E-01
k _AC							32	50,000	8.5E-01	42	50,000	1.0E-01
k _BA							24	50,000	1.0E + 00	50	50,000	7.6E-04
k _FBB							73	50,000	<2.2E-16	1	50,000	1.0E + 00
k _FCC							35	50,000	6.4E-01	39	50,000	2.8E-01
K _AB	44	19,998	9.4E-11	25	19,999	1.7E-03	4	20,000	1.0E + 00	1	20,000	1.0E + 00	0	20,000	1.0E + 00
K _AC	26	20,000	7.4E-04	17	19,999	2.1E-01	17	20,000	2.1E-01	6	20,000	1.0E + 00	8	20,000	9.7E-01
K _BA	33	19,994	4.3E-07	28	20,000	1.1E-04	11	20,000	8.3E-01	2	20,000	1.0E + 00	0	20,000	1.0E + 00
K _FBB	57	19,997	<2.2E-16	17	19,999	2.1E-01	0	19,999	1.0E + 00	0	20,000	1.0E + 00	0	20,000	1.0E + 00
K _FCC	9	19,999	9.4E-01	23	19,999	8.0E-03	32	20,000	1.5E-06	9	20,000	9.4E-01	1	20,000	1.0E + 00

^aIn square brackets are the intervals of parameter values for the indicated class.
^bOut of M (=74) kinetic solutions, x is the number of solutions with the value of the indicated parameter belonging to the indicated value class.
^cOut of a total of N (=10⁵) parameter sets sampled, y is the number of sets with the value of the indicated parameter belonging to the indicated value class.
^dAn enrichment test is considered statistically significant if its p-value < 10^-3 and is highlighted in boldface. Based on p-values (using 10^-3 as threshold), an enrichment state, i.e. motif, was assigned.

ISSN: 1752-0509