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Table 2 Functional association test results for the NFBLB model

From: Understanding system dynamics of an adaptive enzyme network from globally profiled kinetic parameters

Parameter Motif [m]a Non-motif [~m]       Precision testb       Sensitivity testb Functionc
    Prm Pr~m zd Snm Sn~m zd  
k BA [100,101] [10-1,100] 1.81 1.35 30.88 −1.18 −0.76 −8.75 PR
k FBB [10-1,100] [100,101] 1.68 1.45 16.71 −1.16 −0.80 −6.67 PR
K AB [10-3, 10-2] [10-2,102] 1.59 1.42 6.60 −1.40 −0.90 −6.65 PR
K AC [10-3, 10-2] [10-2,102] 1.57 1.52 9.23 1.23 −1.38 26.57 PR,SN
K BA [10-3, 10-1] [10-1,102] 1.76 1.29 35.34 −1.41 −0.68 −12.72 PR
K FBB [10-3, 10-2] [10-2,102] 1.47 2.05 −34.32 −0.61 −1.06 3.95 SN
K FCC [10-1, 100] [10-3, 10-1] and [100, 102] 1.63 1.34 16.98 3.30 −2.31 28.37 PR,SN
  1. aIn square brackets are the intervals of the parameter values, ’m’ is the motif group and ‘~m’ the non-motif group. Note that for the kinetic parameters (k AB , k AC , and k FCC ) showing no apparent bias towards any value classes, the statistical tests were not conducted because their parameter values could not be partitioned into motif group and non-motif group (see Methods).
  2. b“Prm” (“Snm”) is the mean logarithm value of precision (sensitivity) scores for the motif group, and “Pr~m” (“Sn~m”) is the same but for the non-motif group.
  3. c“PR” ( SN”) indicates that the corresponding kinetic motif is statistically significant (z-score 3.29) in improving precision (sensitivity).
  4. dz-score greater than 3.29 (99.9% confidence interval) is highlighted in boldface.