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Table 2 Functional association test results for the NFBLB model

From: Understanding system dynamics of an adaptive enzyme network from globally profiled kinetic parameters

Parameter

Motif [m]a

Non-motif [~m]

      Precision testb

      Sensitivity testb

Functionc

   

Prm

Pr~m

zd

Snm

Sn~m

zd

 

k BA

[100,101]

[10-1,100]

1.81

1.35

30.88

−1.18

−0.76

−8.75

PR

k FBB

[10-1,100]

[100,101]

1.68

1.45

16.71

−1.16

−0.80

−6.67

PR

K AB

[10-3, 10-2]

[10-2,102]

1.59

1.42

6.60

−1.40

−0.90

−6.65

PR

K AC

[10-3, 10-2]

[10-2,102]

1.57

1.52

9.23

1.23

−1.38

26.57

PR,SN

K BA

[10-3, 10-1]

[10-1,102]

1.76

1.29

35.34

−1.41

−0.68

−12.72

PR

K FBB

[10-3, 10-2]

[10-2,102]

1.47

2.05

−34.32

−0.61

−1.06

3.95

SN

K FCC

[10-1, 100]

[10-3, 10-1] and [100, 102]

1.63

1.34

16.98

3.30

−2.31

28.37

PR,SN

  1. aIn square brackets are the intervals of the parameter values, ’m’ is the motif group and ‘~m’ the non-motif group. Note that for the kinetic parameters (k AB , k AC , and k FCC ) showing no apparent bias towards any value classes, the statistical tests were not conducted because their parameter values could not be partitioned into motif group and non-motif group (see Methods).
  2. b“Prm” (“Snm”) is the mean logarithm value of precision (sensitivity) scores for the motif group, and “Pr~m” (“Sn~m”) is the same but for the non-motif group.
  3. c“PR” ( SN”) indicates that the corresponding kinetic motif is statistically significant (z-score 3.29) in improving precision (sensitivity).
  4. dz-score greater than 3.29 (99.9% confidence interval) is highlighted in boldface.