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Figure 6 | BMC Systems Biology

Figure 6

From: Analysis of Wnt signaling β-catenin spatial dynamics in HEK293T cells

Figure 6

Schematic diagrams of Computational Models. (A) Model 1 is a Wnt signaling pathway whole cell model based on the full ODE reconstruction of the Lee et al. (2003) model with alternative binding partners not included and updates on binding affinities for mammalian cells. (B) Model 2 is a simple β-catenin compartment model with nuclear and non-nuclear compartments. Model 2 includes a binding partner for β-catenin and considers diffusion and/or active transport mechanisms. (C) Schematic of computational modelling stages/phases implemented in this study. Two stages were conducted, each having two phases with the experimental data used during optimization for each phase (1A, 1B, 2A and 2B). (Bottom inset) Phase A, steady state analysis where proteins were distributed among the complexes and Phase B, transient analysis due to specific perturbations.

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