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Figure 8 | BMC Systems Biology

Figure 8

From: Analysis of Wnt signaling β-catenin spatial dynamics in HEK293T cells

Figure 8

Role of β-catenin active transport into the nucleus in regulating protein distribution/dynamics in HEK293T cells. Simulation results from the optimization of the simple two compartment model for β-catenin (Model 2) indicate the critical role of active transport in regulating the compartmental distribution and dynamics of β-catenin in HEK293T cells. Model 2 was optimized for the relative change in total β-catenin concentrations (A and B) relative changes in β-catenin compartment concentrations (C and D) and relative change in nuclear/cyto-membrane concentration ratios (data not shown). Simulations are conducted with either active transport switch on (A and C) or switched off (B and D). Simulations with active transport clearly show an improved correlation and fit to the experimental data when compared with simulations without active transport.

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