TY - JOUR AU - Dönitz, Jürgen AU - Wingender, Edgar PY - 2014 DA - 2014/04/24 TI - EndoNet: an information resource about the intercellular signaling network JO - BMC Systems Biology SP - 49 VL - 8 IS - 1 AB - In multicellular organisms, an intercellular signaling network communicates information from the environment or distant tissues to defined target cells. Intercellular signaling (mostly mediated by hormones) can affect the metabolic state and the gene expression program of target cells, thereby coordinating development, homeostasis of the organism and its reactions to external stimuli. Knowledge of the components of the intercellular signaling (specifically: the endocrine) network and their relations is an important, though so far a largely neglected part of systems biology. SN - 1752-0509 UR - https://doi.org/10.1186/1752-0509-8-49 DO - 10.1186/1752-0509-8-49 ID - Dönitz2014 ER -