Topological analysis of the driver metabolites. A) The metabolites in set A (the union of metabolites from the 5000 MDMSs); B) The metabolites in set B (the set of critical and the high-frequency driver metabolites). For the labels in the horizontal axis, "D", "InD", "OutD", "BC", "CC", "CCI", "CCO" respectively represent degree, in-degree, out-degree, betweenness, closeness, in-closeness, out-closeness. The hight of blue, green and brown bars respectively represent the fractions of the driver metabolites with high, medium and low centrality scores. The difference between the fractions for each centrality in B) is greater than that in A). Except for the out-closeness in B), the brown bars are all lower than the blue and green ones for the same centrality, which indicates that the driver metabolites tend to avoid nodes with the high degree (resp., out-degree, in-degrees, betweenness, closeness and in-closeness), while the critical and high-frequency driver metabolites tend to have high out-closeness.