|
Metabolite name
|
Metabolite description
|
Category
|
In-degree
|
|---|
|
5dhf[e]
|
pentaglutamyl folate (DHF)
|
FEM[31]
|
0
|
|
5thf[e]
|
pentaglutamyl folate (THF)
|
FEM[31]
|
0
|
|
ach[e]
|
Acetylcholine
|
FEM[32]
|
0
|
|
adp[e]
|
ADP
|
UM[33]
|
0
|
|
arg-DASH-L[e]
|
L-Arginine
|
UM[33]
|
0
|
|
asp-DASH-L[e]
|
L-Aspartate
|
UM[33]
|
0
|
|
atp[e]
|
ATP
|
UM[33]
|
0
|
|
avite1[e]
|
alpha-Tocopherol
|
FEM[34]
|
0
|
|
biocyt[e]
|
Biocytin
|
FEM[35]
|
0
|
|
cmp[e]
|
CMP
|
UM[33]
|
0
|
|
fe3[e]
|
Fe 3+
|
FEM[36]
|
0
|
|
glygn2[e]
|
glycogen, structure 2
|
EUM
|
0
|
|
gtp[e]
|
GTP
|
UM[33]
|
0
|
|
ha[e]
|
hyaluronan
|
FEM[37]
|
0
|
|
idp[e]
|
IDP
|
FEM[38]
|
0
|
|
ksi[e]
|
keratan sulfate I
|
EUM
|
0
|
|
lcts[e]
|
Lactose
|
EUM
|
0
|
|
Lcystin[e]
|
L-Cystine
|
FEM[39]
|
0
|
|
met-DASH-L[e]
|
L-Methionine
|
UM[33]
|
0
|
|
nac[e]
|
Nicotinate
|
EUM
|
0
|
|
nad[e]
|
Nicotinamide adenine dinucleotide
|
UM[33]
|
0
|
|
nadp[e]
|
Nicotinamide adenine dinucleotide phosphate
|
UM[33]
|
0
|
|
orn[e]
|
Ornithine
|
EUM
|
0
|
|
paf-hs[e]
|
1-alkyl 2-acteylglycerol 3-phosphocholine
|
FEM[40, 41]
|
0
|
|
pe-hs[e]
|
phosphatidylethanolamine
|
FEM[42, 43]
|
0
|
|
pglyc-hs[e]
|
phosphatidylglycerol
|
EUM
|
0
|
|
pnto-DASH-R[e]
|
(R)-Pantothenate
|
FEM[44]
|
0
|
|
ppa[e]
|
Propionate (n-C3:0)
|
FEM[45]
|
0
|
|
s2l2fn2m2masn[e]
|
PA6
|
EUM
|
0
|
|
strch1[e]
|
starch, structure 1
|
FEM[46]
|
0
|
|
sucr[e]
|
Sucrose
|
FEM[47]
|
0
|
|
tagat-DASH-D[e]
|
D-Tagatose
|
EUM
|
0
|
|
tag-hs[e]
|
triacylglycerol
|
FEM[48]
|
0
|
|
ttdca[e]
|
tetradecanoate (n-C14:0)
|
EUM
|
0
|
|
utp[e]
|
UTP
|
UM[33]
|
0
|
|
yvite[e]
|
gamma-Tocopherol
|
FEM[49, 50]
|
0
|
- The compartment abbreviation of all critical driver metabolites are "[e]", which means that their locations are all extracellular. The in-degree of each critical driver metabolite is zero, which implies that each critical driver metabolite is the start metabolite of a metabolic pathway. The categories "UM", "FEM", "EUM" respectively represent the universal metabolites, the functional essential metabolites and the metabolites whose essentiality have not been discovered.
