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Table 2 The list of the critical driver metabolites in the HLMN

From: Detection of driver metabolites in the human liver metabolic network using structural controllability analysis

Metabolite name Metabolite description Category In-degree
5dhf[e] pentaglutamyl folate (DHF) FEM[31] 0
5thf[e] pentaglutamyl folate (THF) FEM[31] 0
ach[e] Acetylcholine FEM[32] 0
adp[e] ADP UM[33] 0
arg-DASH-L[e] L-Arginine UM[33] 0
asp-DASH-L[e] L-Aspartate UM[33] 0
atp[e] ATP UM[33] 0
avite1[e] alpha-Tocopherol FEM[34] 0
biocyt[e] Biocytin FEM[35] 0
cmp[e] CMP UM[33] 0
fe3[e] Fe 3+ FEM[36] 0
glygn2[e] glycogen, structure 2 EUM 0
gtp[e] GTP UM[33] 0
ha[e] hyaluronan FEM[37] 0
idp[e] IDP FEM[38] 0
ksi[e] keratan sulfate I EUM 0
lcts[e] Lactose EUM 0
Lcystin[e] L-Cystine FEM[39] 0
met-DASH-L[e] L-Methionine UM[33] 0
nac[e] Nicotinate EUM 0
nad[e] Nicotinamide adenine dinucleotide UM[33] 0
nadp[e] Nicotinamide adenine dinucleotide phosphate UM[33] 0
orn[e] Ornithine EUM 0
paf-hs[e] 1-alkyl 2-acteylglycerol 3-phosphocholine FEM[40, 41] 0
pe-hs[e] phosphatidylethanolamine FEM[42, 43] 0
pglyc-hs[e] phosphatidylglycerol EUM 0
pnto-DASH-R[e] (R)-Pantothenate FEM[44] 0
ppa[e] Propionate (n-C3:0) FEM[45] 0
s2l2fn2m2masn[e] PA6 EUM 0
strch1[e] starch, structure 1 FEM[46] 0
sucr[e] Sucrose FEM[47] 0
tagat-DASH-D[e] D-Tagatose EUM 0
tag-hs[e] triacylglycerol FEM[48] 0
ttdca[e] tetradecanoate (n-C14:0) EUM 0
utp[e] UTP UM[33] 0
yvite[e] gamma-Tocopherol FEM[49, 50] 0
  1. The compartment abbreviation of all critical driver metabolites are "[e]", which means that their locations are all extracellular. The in-degree of each critical driver metabolite is zero, which implies that each critical driver metabolite is the start metabolite of a metabolic pathway. The categories "UM", "FEM", "EUM" respectively represent the universal metabolites, the functional essential metabolites and the metabolites whose essentiality have not been discovered.