Figure 2

Graphical representation of the model structure in SBGN for: (A) ASYN and DA production and (B) ASYN oligomerization and modification sub-models. (A) WT ASYN (WTasyn) and DA (Dopamine) are produced by SOURCE (see text for details). The WT ASYN is modified by DA to form the modified ASYN Monomer (DopModWTasyn). The DA species are degraded by a simple degradation reaction. (B) WT (WTasyn-WTasyn9) and DA-modified (DopModWTasyn-DopModWTasyn9) can form oligomers of higher order (black colored reactions) by the addition of a monomer. Moreover, oligomers could dissociate to oligomers of a lower order by freeing a monomer species (red colored reactions). Only WT ASYN species can form HMW species (HigherWTasynSPC).