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Table 2 Pathways with significant dysregulation in long-lived D. melanogaster

From: Network topology-based detection of differential gene regulation and regulatory switches in cell metabolism and signaling

Pathway P* Up* No_ch* Down*
Starch and sucrose metabolism 2.71E-03 6 11 1
Circadian rhythm - fly 7.90E-03 3 5 0
Glycerophospholipid metabolism 1.02E-02 9 25 3
Tyrosine metabolism 1.44E-02 4 5 0
Nicotinate and nicotinamide metabolism 2.23E-02 3 6 0
Glycine, serine and threonine metabolism 2.97E-02 4 14 3
Jak-STAT signaling pathway 3.15E-02 1 11 2
Ubiquinone and other terpenoid-quinone biosynthesis 3.26E-02 7 4 0
Endocytosis 4.52E-02 6 16 1
Purine metabolism 4.87E-02 23 49 9
  1. *Up is the number of up-regulated reactions in long-lived flies when compared to normal controls, down the number of down-regulated reactions; and no_ch the number of reactions without notable changes. P is the Bonferroni corrected P-value for the pathway pattern.