|
Ca
50ref
|
Calcium sensitivity at resting sarcomere length (mM)
|
0.3e-3
|
0.8e-3
|
0.3e-3
|
|
k
refoff
|
Unbinding rate of Ca from TnC in the absence of tension (ms-1)
|
0
|
0.80
|
0.2
|
|
k
on
|
Binding rate of Ca to TnC (μM-1 s-1)
|
0
|
400
|
100
|
|
n
r
|
Relaxation parameter
|
2
|
4
|
3
|
|
β
0
|
Magnitude of length-dependent activation effects
|
1
|
5
|
4.9
|
|
β
1
|
Magnitude of filament overlap effects
|
-8
|
0
|
-4
|
|
γ
|
Effect of tension on the unbinding rate of Ca from TnC
|
2
|
100
|
2
|
|
nH
|
Hill coefficient in the steady-state force-pCa curve
|
4
|
9
|
5
|
|
T
ref
|
Reference tension (kPa)
|
100
|
140
|
100
|
|
α
0
|
Monoexponential activation rate seen in caged Ca experiments (ms-1)
|
0
|
0.048
|
0.008
|
|
α
r1
|
Slow relaxation rate (ms-1)
|
0
|
0.012
|
0.002
|
|
α
r2
|
Fast relaxation rate (ms-1)
|
0
|
0.0105
|
0.00175
|
|
K
z
|
Relaxation parameter
|
0.1
|
0.2
|
0.15
|
