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Table 3 Description of the output metrics used to describe the force-pCa relationship

From: Insight into model mechanisms through automatic parameter fitting: a new methodological framework for model development

Metric

Description

Land-model default output*

Slope

Slope of the fitted line

-7.33

Intercept

Intercept of the fitted line

45.9

RMSEP

Root Mean Square Error of prediction from fitting to a straight line (representing the deviation from a straight line)

0.18

R 2 force

Correlation coefficient between the fitted line and the simulated force-pCa data (representing the deviation from a straight line)

0.99

Max

Maximum tension

119.4

RMSDforce

RMSD between the simulated force for the Niederer-model and the target Land-model force (in standardised variables)

0

  1. These metrics were calculated from simulations using fixed Ca-concentrations.
  2. *From a simulation at resting sarcomere length.