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Table 4 Constraints used on some of the Niederer-model parameters used in the parameter fitting

From: Insight into model mechanisms through automatic parameter fitting: a new methodological framework for model development

Parameter Minimum value Maximum value
k refoff 0.05 0.4
k on 50 300
n r 1 -
β 0 - 6
γ 1 5
nH 1 15
T ref 90 140