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Table 6 Niederer-model parameter values corresponding to the model output values closest to the target

From: Insight into model mechanisms through automatic parameter fitting: a new methodological framework for model development

Parameter Parameter set 1 Parameter set 2 Parameter set 3 Mean value Standard deviation
Ca 50ref 0.31e-3 0.33e-3 0.35e-3 0.33e-3 2.21e-5
k refoff 0.08 0.12 0.08 0.09 0.03
k on 227.2 163.1 186.7 192.3 32.4
n r 1.38 1.66 2.02 1.68 0.32
β 0 0.10 0.06 0.07 0.08 0.02
β 1 -1.35 -1.14 -1.29 -1.26 0.11
γ 3.99 4.75 4.79 4.51 0.45
nH 13.48 10.23 12.09 11.93 1.63
T ref 135.8 130.6 115.8 127.4 10.4
α 0 0.03 0.03 0.06 0.04 0.02
α r1 0.48 0.46 0.43 0.46 0.02
α r2 0.009 0.016 0.010 0.01 3.97e-3
K z 0.07 0.10 0.07 0.08 0.02
  1. Model outputs were matched to target data for 90, 100 and 110% of resting sarcomere length.