Insight into model mechanisms through automatic parameter fitting: a new methodological framework for model development

Table 6 Niederer-model parameter values corresponding to the model output values closest to the target

Parameter	Parameter set 1	Parameter set 2	Parameter set 3	Mean value	Standard deviation
Ca _50ref	0.31e-3	0.33e-3	0.35e-3	0.33e-3	2.21e-5
k _refoff	0.08	0.12	0.08	0.09	0.03
k _on	227.2	163.1	186.7	192.3	32.4
n _r	1.38	1.66	2.02	1.68	0.32
β ₀	0.10	0.06	0.07	0.08	0.02
β ₁	-1.35	-1.14	-1.29	-1.26	0.11
γ	3.99	4.75	4.79	4.51	0.45
nH	13.48	10.23	12.09	11.93	1.63
T _ref	135.8	130.6	115.8	127.4	10.4
α ₀	0.03	0.03	0.06	0.04	0.02
α _r1	0.48	0.46	0.43	0.46	0.02
α _r2	0.009	0.016	0.010	0.01	3.97e-3
K _z	0.07	0.10	0.07	0.08	0.02

Model outputs were matched to target data for 90, 100 and 110% of resting sarcomere length.

ISSN: 1752-0509