Figure 2

The integrated graph G with two edge types/states (2A) shows individual clusters from differing networks that are indeed connected by one or a few nodes between clusters. The gateway nodes, highlighted in 2A as larger yellow diamond nodes, are not hubs in the traditional sense (i.e., as in an interactome). Figure 2B represents the network with the nodes removed (arrows representing the clusters they connect) highlights that this special sets of nodes becomes a minimum cut set between the YNG and MID networks.