Figure 1

Schematic representation of the network analysis workflow. Seed genes provide information on neurodegenerative dementia diseases-associated genes in the OMIM database and on primary molecular drug targets in the different phases of the drug discovery process. Following reconstruction of the protein-protein interaction (PPI) network derived from the integration of seed genes (disease genes and drug targets) and I2D database, we characterized the functional enrichment of the protein in the network by testing over-represented Gene Ontology biological process terms.