A systems biology investigation of neurodegenerative dementia reveals a pivotal role of autophagy

BMC Systems Biology

Table 3 List of high-ranked proteins in the dementia network using the degree index

Uniprot ID	Official gene symbol	Gene name	Degree index
Q13131	PRKAA1	Protein kinase, AMP-activated, alpha 1 catalytic subunit	419
P54646	PRKAA2	Protein kinase, AMP-activated, alpha 2 catalytic subunit	392
P03372	ESR1	Estrogen receptor 1	250
P19838	NFKB1	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	247
Q13547	HDAC1	Histone deacetylase 1	218
Q00005	PPP2R2B	Protein phosphatase 2 (formerly 2A), regulatory subunit B, beta isoform	201
P17252	PRKCA	Protein kinase C, alpha	194
P49841	GSK3B	Glycogen synthase kinase 3 beta	170
P06493	CDK11	Cell division cycle 2, G1 to S and G2 to M	163
P04150	NR3C1	Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	156
Q92769	HDAC2	Histone deacetylase 2	138
P05067	APP	Amyloid beta (A4) precursor protein	136
P19438	TNFRSF1A	Tumor necrosis factor receptor superfamily, member 1A	133
P67775	PPP2CA	Protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	127
P20226	TBP	TATA box binding protein	126
P24941	Cdk2	Cyclin-dependent kinase 2	125
P30153	PPP2R1A	Protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform	121
P54259	ATN1	Atrophin 1	109
P50750	CDK9	Cyclin-dependent kinase 9	102

In bold is the mediator which is also disease proteins, having direct interactions with drug targets and other disease genes.

ISSN: 1752-0509