Figure 6

Number of flux changes vs. glucose uptake. Starting from the optimal growth state (glucose uptake 10), minimization of flux adjustment was used to calculate the final states (glucose uptakes smaller than 10). We show the number of fluxes that increase to more than double (red square curve), the number of fluxes that decrease to less than one tenth (blue circle curve) and their sum (black circle curve). In A, growth rate is fixed at the maximum value. High numbers of changing fluxes only appear for low glucose uptakes, when a substantial proportion of the fluxes are forced to take very low values. For this type of adaptations, large changes in only a small proportion of the fluxes take place. In B, growth rate is free. The number of fluxes that change is high in all the interval of glucose uptakes. Adaptations with growth variation produce global reorganization of the flux pattern in all the interval of glucose uptakes.