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Table 10 Distribution of signalling related functions in HFPIN and CN zones

From: Modelling human protein interaction networks as metric spaces has potential in disease research and drug target discovery

 

HPFIN

CN

Function

Zone 1

Zone 2

Zone 3

Zone 1

Zone 2

Zone 3

Signalling

285 (76.2%)

2141 (46.4%)

760 (20.8%)

397 (73.2%)

2434 (40.4%)

640 (19%)

Positive regulation

75 (20%)

386 (8.3%)

83 (2.2%)

123 (22.6%)

393 (6.5%)

50 (1.4%)

Negative regulation

57 (15.2%)

321 (6.9%)

71 (1.9%)

82 (15.1%)

344 (5.7%)

54 (1.6%)

MAPK signalling

93 (24.8%)

258 (5.5%)

43 (1.1%)

139 (25.6%)

249 (4.1%)

20 (0.5%)