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Table 10 Distribution of signalling related functions in HFPIN and CN zones

From: Modelling human protein interaction networks as metric spaces has potential in disease research and drug target discovery

  HPFIN CN
Function Zone 1 Zone 2 Zone 3 Zone 1 Zone 2 Zone 3
Signalling 285 (76.2%) 2141 (46.4%) 760 (20.8%) 397 (73.2%) 2434 (40.4%) 640 (19%)
Positive regulation 75 (20%) 386 (8.3%) 83 (2.2%) 123 (22.6%) 393 (6.5%) 50 (1.4%)
Negative regulation 57 (15.2%) 321 (6.9%) 71 (1.9%) 82 (15.1%) 344 (5.7%) 54 (1.6%)
MAPK signalling 93 (24.8%) 258 (5.5%) 43 (1.1%) 139 (25.6%) 249 (4.1%) 20 (0.5%)